cAMP regulation of airway smooth muscle function
نویسندگان
چکیده
منابع مشابه
Mast cell regulation of airway smooth muscle function in asthma.
A sthma is a common disease affecting f10% of the adult Western population [1, 2]. It is characterised by the presence of variable and potentially reversible airflow obstruction, which occurs as the result of bronchoconstriction, airway mucus plugging and airway oedema. Pathologically there is evidence of airway inflammation and remodelling [3– 7]. The mucosal inflammatory infiltrate commonly c...
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The immuno-modulatory properties of airway smooth muscle have become of increasing importance in our understanding of the mechanisms underlying chronic inflammation and structural remodeling of the airway wall in asthma and chronic obstructive pulmonary disease (COPD). ASM cells respond to many cytokines, growth factors and lipid mediators to produce a wide array of immuno-modulatory molecules ...
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Autonomic nerves in most mammalian species mediate both contractions and relaxations of airway smooth muscle. Cholinergic-parasympathetic nerves mediate contractions, whereas adrenergic-sympathetic and/or noncholinergic parasympathetic nerves mediate relaxations. Sympathetic-adrenergic innervation of human airway smooth muscle is sparse or nonexistent based on histological analyses and plays li...
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Goldsmith AM, Hershenson MB, Wolbert MP, Bentley JK. Regulation of airway smooth muscle -actin expression by glucocorticoids. Am J Physiol Lung Cell Mol Physiol 292: L99–L106, 2007. First published September 15, 2006; doi:10.1152/ajplung.00269.2006.—Airway smooth muscle hypertrophy appears to be present in severe asthma. However, the effect of corticosteroids on airway smooth muscle cell size o...
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To elucidate the role of specific proinflammatory cytokines in regulating airway responsiveness, we examined the effects and mechanisms of action of IL-1 b , TNFa , and IL-2 on the b -adrenoceptor– and postreceptor-coupled transmembrane signaling mechanisms regulating relaxation in isolated rabbit tracheal smooth muscle (TSM) segments. During half-maximal isometric contraction of the tissues wi...
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ژورنال
عنوان ژورنال: Pulmonary Pharmacology & Therapeutics
سال: 2013
ISSN: 1094-5539
DOI: 10.1016/j.pupt.2012.05.007